Dr. March D. Ard

March D. Ard, Ph.D.

Associate Professor of Anatomy
Department of Anatomy
The University of Mississippi Medical Center
2500 North State Street
Jackson, Mississippi 39216-4505

Office Telephone: 601-984-1645
Department FAX:   601-984-1655
      : mard@anatomy.umsmed.edu

Interests

I'm interested in glial cells of the central nervous system, particularly in how microglia are involved in Alzheimer's disease. Microglia in amyloid plaques may contribute to plaque deposition and turnover, and microglial immune responses are part of the inflammatory response that occurs in the brain in Alzheimer's disease. We're studying microglial secretion of inflammatory signaling molecules in cell culture using immunocytochemistry, enzyme-linked immunoassay, gel electrophoresis, and electron microscopy.

I teach medical Microscopic Anatomy (histology) and especially enjoy the cell biology included in the course.

 

Current Publication in pdf Format:

Chen, S., Averett, N.T., Manelli, A., LaDu, M.J., and Ard, M.D. 2005 Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia. Journal of Alzheimer's Disease 7:25-35.

Selected Publications

  1. D'Andrea, M.R., Cole, G.M., and Ard, M.D. 2004 A review of the microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol. Aging 25:675-683.
  2. Cole, G.M. and Ard, M.D. 2000 Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Microscopy Research and Technique 50(4):316-324.
  3. Sundaram, N., Pahwa, A.K., Ard, M.D., Lin, N., Perkins, E., and Bowles, A.P., Jr. 2000 The differential effect of selenium on human brain tumor cells and normal fibroblasts. J. Neuro-Oncology 46:125-133.
  4. Cole, G.M., Beech, W., Frautschy, S.A., Sigel, J., Glasgow, C., and Ard, M.D. 1999 Lipoprotein effects on A-ß accumulation and degradation by microglia in vitro. Journal of Neuroscience Research 57:504-520.
  5. Mohan, P.F. and Ard, M.D. 1996 Induction of microglial nitric oxide synthesis by very low density lipoprotein. Glia 17:259-262.
  6. Ard, M.D., Cole, G.M., Mehrle, A.P., Wei, J. and Fratkin, J.D. 1996 Scavenging of Alzheimer's amyloid ß-protein by microglia in culture. J. Neurosci. Res. 43:190-202.
  7. Ard, M.D., Schachner, M., Rapp, J. and Faissner, A. 1993 Growth and degeneration of axons on astrocyte surfaces: effects on extracellular matrix and on later axonal growth. Glia 9:248-259.
 color micrograph
Cultured adult human microglia with autofluorescent lysosomes and FITC-immunolabeled (green) Alzheimer's amyloid ß-protein.

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